Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles by Kevin H. Shaughnessy,Engelbert Ciganek,Rebecca B.

By Kevin H. Shaughnessy,Engelbert Ciganek,Rebecca B. DeVasher,Scott E. Denmark

The metal-catalyzed amination of aryl and alkenyl electrophiles has constructed right into a regularly occurring technique for the synthesis of traditional items, energetic pharmaceutical constituents, agricultural chemical substances, and fabrics for molecular electronics. Copper catalysts advertise the coupling of a variety of nitrogen nucleophiles, together with amines, amides, and heteroaromatic nitrogen compounds with aryl and alkenyl halides. The reactivity profile of copper catalysts is complementary to that of palladium catalysts in lots of instances. Copper catalysts are powerful with much less nucleophilic nitrogen nucleophiles, resembling amides and azoles, while palladium catalysts are greater with extra nucleophilic amine nucleophiles. Copper is an enticing substitute to palladium because of its considerably cheaper price. additionally, excessive job palladium catalysts require pricey and infrequently air-sensitive ligands, while the fashionable copper platforms use really strong and cheap diamine or amino acid ligands. Copper-catalyzed C?N coupling reactions are tolerant of a variety of sensible teams and feature been utilized to the synthesis of numerous complicated usual items. major paintings has additionally been performed to appreciate the mechanism of those reactions. present mechanistic knowing of those methodologies is roofed during this monograph.

The contents of the publication are taken from the great evaluation of the subject within the natural Reactions sequence. optimum experimental stipulations for the amination of aryl and alkenyl halides with all periods of nitrogen nucleophiles are offered. particular experimental methods from the literature are supplied for the main periods of copper-catalyzed C?N coupling reactions. A tabular survey of all examples of Cu-catalyzed arylation and alkenylation of nitrogen nucleophiles is gifted in 35 tables equipped by way of nitrogen nucleophile and electrophilic coupling partner.

The literature is roofed via December 2015 and gives three hundred contemporary citations to complement the 680 citations of the unique hardbound bankruptcy. those newest literature references were gathered in separate sections in line with the series of the tables within the tabular survey part. In all of the sections, the person citations were prepared in alphabetic order of the writer names.
Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles is meant to supply natural chemists with an obtainable, yet special, creation to this significant classification of transformations.

Show description

Read or Download Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles PDF

Best physical & theoretical chemistry books

Nano Plating - Microstructure Formation Theory of Plated Films and a Database of Plated Films

Smooth plating expertise is very complicated, and has built to hide quite a lot of functions. as well as the normal use for floor completing, plating know-how can now provide novel methods to manufacture high-performance motion pictures or fantastic microstructural our bodies within the microelectronics undefined.

Silanes and Other Coupling Agents, Volume 5

The subject of silanes and different coupling agents/adhesion promoters is of great modern curiosity as a result of their software in lots of and sundry technologically very important components starting from coatings to strengthened composites to dentistry to biomedical (e. g. , for bonding nucleotides to the so-called ‘gene chips’).

Surfactants in Tribology, Volume 3

The manufacture and use of just about each shopper and commercial product depend upon software of complex wisdom in floor technology and tribology. those disciplines are of severe significance in significant financial sectors, comparable to mining, agriculture, production (including metals, plastics, wooden, desktops, MEMS, NEMS, appliances), development, transportation, and scientific tools, transplants, and diagnostic units.

Graphene Oxide: Fundamentals and Applications

As a result of its certain homes, graphene oxide has turn into the most studied fabrics of the decade and a very good number of purposes were pronounced in parts akin to sensors, catalysis and biomedical purposes. This finished quantity systematically describes the elemental points and functions of graphene oxide.

Extra info for Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles

Example text

Download PDF sample

Rated 4.61 of 5 – based on 21 votes